High Performance Computer Simulations for the Study of Biological Function in 3D Heart Models Incorporating Fibre Orientation and Realistic Geometry at Para−Cellular Resolution

Abstract

Information regarding the propagation dynamics of intramural electrical wavefronts in the 3D volume of the ventricles is critical in gaining a better understanding of normal and pathological cardiac function. However investigation into such phenomena using cardiac modelling has so far been impaired due to limitations in the structural details included in current cardiac computational models. Here, we describe the technological pipeline required for the construction of realistic, highly-detailed and personalised whole ventricular models directly from high-resolution MR images