Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Models

Paci et al. 2020

Download: Matlab code available on request

Journal Paper: All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation
Paci M, Passini E, Klimas A, Severi S, Hyttinen J, Rodriguez B, Entcheva E. Biophys J. 2020.

Kernik et al. 2019

Download: Code available on GitHub

Journal Paper: A computational model of induced pluripotent stem‐cell derived cardiomyocytes incorporating experimental variability from multiple data sources Kernik DC, Morotti S, Duff HJ, Kurokawa J, Jalife J, Wu JC, Grandi E, Clancy CE. J Physiol. 2019.

Paci et al. 2018

Download: Matlab code available on request

Journal Paper: Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities
Paci M, Pölönen RP, Cori D, Penttinen K, Aalto-Setälä K, Severi S, Hyttinen J. Front Physiol. 2018.

Koivumäki et al. 2018

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Journal Paper: Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling
Koivumäki JT, Naumenko N, Tuomainen T, Takalo J, Oksanen M, Puttonen KA, Lehtonen Š, Kuusisto J, Laakso M, Koistinaho J and Tavi P. Front Physiol. 2018.

Paci et al. 2013

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Journal Paper: Computational models of ventricular- and atrial-like human induced pluripotent stem cell derived cardiomyocytes
Paci M, Hyttinen J, Aalto-Setälä K, Severi S. Ann Biomed Eng. 2013.

Human Embryonic Stem Cell Derived Cardiomyocyte Models

Paci et al. 2012

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Journal Paper: Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes
Paci M, Sartiani L, Del Lungo M, Jaconi M, Mugelli A, Cerbai E, Severi S. BioMed Eng Online. 2012.