Elisa Passini : Publications
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@article{Trovato2017,
title = "{In silico trials in human ventricular and purkinje cell models predict safety and efficacy of 10 antiarrhythmic drugs}",
author = "Trovato, C. and Passini, E. and Tissier, A. and Nagy, N. and Varro', A. and Severi, S. and Rodriguez, B.",
year = "2017",
issn = "1099-5129",
journal = "EP Europace",
keywords = "anti-arrhythmia agents,heart ventricle,purkinje cells,safety",
month = "jun",
number = "suppl{\_}3",
pages = "iii116--iii116",
publisher = "Oxford University Press",
url = "https://academic.oup.com/europace/article-lookup/doi/10.1093/ehjci/eux140.007",
volume = "19",
doi = "10.1093/ehjci/eux140.007",
}
@article{Paci2017,
title = "{Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: An in silico approach}",
author = "Paci, Michelangelo and Passini, Elisa and Severi, Stefano and Hyttinen, Jari and Rodriguez, Blanca",
year = "2017",
journal = "Heart Rhythm",
keywords = "Action potential,Drug test,Human induced pluripotent stem cell-derived cardio,In silico modeling,Long QT syndrome type 3,Population of models",
month = "nov",
number = "11",
pages = "1704--1712",
url = "http://www.ncbi.nlm.nih.gov/pubmed/28756098 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5668441 http://linkinghub.elsevier.com/retrieve/pii/S1547527117308949",
volume = "14",
doi = "10.1016/j.hrthm.2017.07.026",
}
@article{Passini2017,
title = "{Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity}",
author = "Passini, Elisa and Britton, Oliver J. and Lu, Hua R. and Rohrbacher, Jutta and Hermans, An N. and Gallacher, David J. and Greig, Robert J. H. and Bueno-Orovio, Alfonso and Rodriguez, Blanca",
year = "2017",
issn = "1664-042X",
journal = "Frontiers in Physiology",
keywords = "computer models,drug cardiotoxicity,drug safety,human,in silico drug trials,in silico drug trials, drug safety, drug cardiotox,torsade de pointes,ventricular action potential",
number = "September",
pages = "1--15",
url = "http://journal.frontiersin.org/article/10.3389/fphys.2017.00668/full",
volume = "8",
doi = "10.3389/fphys.2017.00668",
}
@article{GEMMELL2017203,
title = "{Investigations of iPS Cell-Derived Cardiomyocyte Electrophysiology Using an Experimentally Calibrated Population of Models}",
author = "Gemmell, Philip and Passini, Elisa and Rodriguez, Blanca and Burton, Francis and Smith, Godfrey",
year = "2017",
issn = "1056-8719",
journal = "Journal of Pharmacological and Toxicological Methods",
number = "Part 2",
pages = "203",
url = "http://www.sciencedirect.com/science/article/pii/S1056871917303416",
volume = "88",
doi = "https://doi.org/10.1016/j.vascn.2017.09.114",
}
@article{PASSINI2017208,
title = "{In Silico Drug Trials with Virtual Assay Software Predict Drug Cardiotoxicity and Identify Sub-Populations at Higher Risk}",
author = "Passini, Elisa and Britton, Oliver and Bueno-Orovio, Alfonso and Rodriguez, Blanca",
year = "2017",
issn = "1056-8719",
journal = "Journal of Pharmacological and Toxicological Methods",
number = "Part 2",
pages = "208--209",
url = "http://www.sciencedirect.com/science/article/pii/S105687191730360X",
volume = "88",
doi = "https://doi.org/10.1016/j.vascn.2017.09.133",
}
@article{PACI2017240,
title = "{In Silico Modeling of Human iPS Cardiomyocytes: Effect of Drugs and Comparison to Human Adult Cardiomyocytes}",
author = "Paci, Michelangelo and Passini, Elisa and Severi, Stefano and Hyttinen, Jari and Rodriguez, Blanca",
year = "2017",
issn = "1056-8719",
journal = "Journal of Pharmacological and Toxicological Methods",
number = "Part 2",
pages = "240--241",
url = "http://www.sciencedirect.com/science/article/pii/S105687191730463X",
volume = "88",
doi = "https://doi.org/10.1016/j.vascn.2017.09.236",
}
@article{PASSINI2017209,
title = "{A Novel In Silico Human Cardiac Purkinje Cell Model to Investigate Drug Safety and Efficacy}",
author = "Passini, Elisa and Trovato, Cristian and Tissier, Antoine and Nagy, Norbert and Varro, Andras and Severi, Stefano and Rodriguez, Blanca",
year = "2017",
issn = "1056-8719",
journal = "Journal of Pharmacological and Toxicological Methods",
number = "Part 2",
pages = "209",
url = "http://www.sciencedirect.com/science/article/pii/S1056871917303611",
volume = "88",
doi = "https://doi.org/10.1016/j.vascn.2017.09.134",
}
@article{Rodriguez2016,
title = "{Human-based approaches to pharmacology and cardiology: An interdisciplinary and intersectorial workshop}",
author = "Rodriguez, Blanca and Carusi, Annamaria and Abi-Gerges, Najah and Ariga, Rina and Britton, Oliver Jonathan and Bub, Gil and Bueno-Orovio, Alfonso and Burton, Rebecca A B and Carapella, Valentina and Cardone-Noott, Louie and Daniels, Matthew J. and Davies, Mark R. and Dutta, Sara and Ghetti, Andre and Grau, Vicente and Harmer, Stephen and Kopljar, Ivan and Lambiase, Pier and Lu, Hua Rong and Lyon, Aurore and Minchol{\'{e}}, Ana and Muszkiewicz, Anna and Oster, Julien and Paci, Michelangelo and Passini, Elisa and Severi, Stefano and Taggart, Peter and Tinker, Andy and Valentin, Jean-Pierre and Varr{\'{o}}, Andr{\'{a}}s and Wallman, Mikael and Zhou, Xin",
year = "2016",
isbn = "10995129 (ISSN)",
issn = "15322092",
journal = "Europace",
keywords = "Arrhythmias,Biomarkers,Computational approaches,Computer modelling and simulations,Human electrophysiology,Human-based methods,Stem-cell-derived cardiomyocytes",
month = "sep",
number = "9",
pages = "1287--1298",
url = "http://europace.oxfordjournals.org/lookup/doi/10.1093/europace/euv320",
volume = "18",
doi = "10.1093/europace/euv320",
}
@article{Muszkiewicz2016,
title = "{Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm}",
author = "Muszkiewicz, Anna and Britton, Oliver Jonathan and Gemmell, Philip and Passini, Elisa and Sanchez, Carlos and Zhou, Xin and Carusi, Annamaria and Quinn, T Alexander and Burrage, Kevin and Bueno-Orovio, Alfonso and Rodriguez, Blanca and S{\'{a}}nchez, Carlos and Zhou, Xin and Carusi, Annamaria and Burrage, Kevin and Bueno-Orovio, Alfonso and Rodriguez, Blanca",
year = "2016",
issn = "00796107",
journal = "Progress in Biophysics and Molecular Biology",
keywords = "Action potential,Arrhythmias,Cardiac electrophysiology,In silico high-throughput screening,Physiological variability,Populations of models",
month = "dec",
number = "1",
pages = "115--127",
url = "http://www.ncbi.nlm.nih.gov/pubmed/26701222 http://www.sciencedirect.com/science/article/pii/S0079610715002424 http://linkinghub.elsevier.com/retrieve/pii/S0079610715002424",
volume = "120",
doi = "10.1016/j.pbiomolbio.2015.12.002",
}
@article{PASSINI2016345,
title = "{In silico prediction of drug effects on human ventricular electrophysiology using the Virtual Assay software and comparison to in vitro data}",
author = "Passini, Elisa and Britton, Oliver and Lu, Hua Rong and Gallacher, David J and Rohrbacher, Jutta and An, Hermans and Bueno-Orovio, Alfonso and Rodriguez, Blanca",
year = "2016",
annote = "Focused Issue on Safety Pharmacology",
issn = "1056-8719",
journal = "Journal of Pharmacological and Toxicological Methods",
number = "Supplement C",
pages = "345--346",
url = "http://www.sciencedirect.com/science/article/pii/S1056871916000381",
volume = "81",
doi = "https://doi.org/10.1016/j.vascn.2016.02.037",
}
@article{Paci2016,
title = "{A population of in silico models to face the variability of human induced pluripotent stem cell-derived cardiomyocytes: The hERG block case study}",
author = "Paci, M and Passini, E and Severi, S and Hyttinen, J and Rodriguez, B",
year = "2016",
isbn = "VO -",
issn = "2325887X",
journal = "Computing in Cardiology",
keywords = "Biological system modeling,Biomarkers,Computational modeling,EAD,IKr block,In vitro,Safety,Sociology,Statistics,action potentials,bioelectric potentials,cellular biophysics,experimental data variability,experimental data-based calibration,external perturbation,final population,hERG block case study,hiPSC-CM models,human induced pluripotent stem cell-derived cardio,ionic currents,maximum conductances,medical computing,normally beating,parameter sets,patient treatment,physiological variability,repolarization failures,safety pharmacology assays,single in silico model",
pages = "345--232",
volume = "43",
doi = "10.22489/CinC.2016.345-232",
}
@article{Passini2015,
title = "Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy ",
author = "Elisa Passini and Ana Mincholé and Raffaele Coppini and Elisabetta Cerbai and Blanca Rodriguez and Stefano Severi and Alfonso Bueno-Orovio",
year = "2015",
issn = "0022-2828",
journal = "Journal of Molecular and Cellular Cardiology ",
keywords = "Hypertrophic cardiomyopathy;, Pro-arrhythmic mechanisms;, Repolarization reserve;, Inter-subject variability;, In silico drug testing ",
pages = "- ",
url = "http://www.sciencedirect.com/science/article/pii/S0022282815300560",
doi = "http://dx.doi.org/10.1016/j.yjmcc.2015.09.003",
}
@article{Vincenti2014396,
title = "{Recurrent intradialytic paroxysmal atrial fibrillation: Hypotheses on onset mechanisms based on clinical data and computational analysis}",
author = "Vincenti, Antonio and Passini, Elisa and Fabbrini, Paolo and Luise, Maria Carmen and Severi, Stefano and Genovesi, Simonetta",
year = "2014",
isbn = "1532-2092 (Electronic)$\backslash$r1099-5129 (Linking)",
issn = "15322092",
journal = "Europace",
keywords = "Atrial fibrillation,Computational modelling,Electrolytes,Haemodialysis,P-wave",
month = "mar",
number = "3",
pages = "396--404",
url = "http://www.ncbi.nlm.nih.gov/pubmed/24569894",
volume = "16",
doi = "10.1093/europace/eut346",
}
@article{Passini2014a,
title = "{Human atrial cell models to analyse haemodialysis-related effects on cardiac electrophysiology: Work in progress}",
author = "Passini, Elisa and Genovesi, Simonetta and Severi, Stefano",
year = "2014",
issn = "17486718",
journal = "Computational and Mathematical Methods in Medicine",
pages = "1--18",
url = "http://www.hindawi.com/journals/cmmm/2014/291598/",
volume = "2014",
doi = "10.1155/2014/291598",
}
@article{Passini2014,
title = "{Late Sodium Current Inhibition Counteracts Pro-arrhythmic Mechanisms in Human Hypertrophic Cardiomyopathy}",
author = "Passini, Elisa and Rodriguez, Blanca and Minchol{\'{e}}, Ana and Coppini, Raffaele and Cerbai, Elisabetta and Severi, Stefano and Bueno-Orovio, Alfonso",
year = "2014",
issn = "2325887X 23258861",
journal = "Computing in Cardiology",
number = "January",
pages = "861--864",
volume = "41",
}
@article{Passini2013a,
title = "{Computational Analysis of Head-Down Bed Rest Effects on Cardiac Action Potential Duration}",
author = "Passini, Elisa and Pellegrini, Alessandro and Caiani, Enrico G. and Severi, Stefano",
year = "2013",
journal = "Computing in Cardiology",
pages = "357--360",
volume = "40",
}
@article{Passini2013,
title = "{Extracellular Calcium and L-Type Calcium Current Inactivation Mechanisms: a Computational Study}",
author = "Passini, Elisa and Severi, Stefano",
year = "2013",
isbn = "9781479908844",
issn = "23258861 2325887X",
journal = "Computing in Cardiology",
pages = "839--842",
volume = "40",
}
@article{Passini2012,
title = "{Computational analysis of extracellular calcium effects on an improved human ventricular action potential model}",
author = "Passini, Elisa and Severi, Stefano",
year = "2012",
journal = "Computing in Cardiology",
pages = "873--876",
url = "http://ieeexplore.ieee.org/xpls/abs{\_}all.jsp?arnumber=6420533",
volume = "39",
}