Gary Mirams : Publications
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@article{Kar2016,
title = "Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals",
author = "P Kar and GR Mirams and HC Christian and AB Parekh",
year = "2016",
journal = "Molecular Cell",
number = "4",
pages = "746-759",
url = "http://www.sciencedirect.com/science/article/pii/S1097276516307195",
volume = "64",
doi = "10.1016/j.molcel.2016.11.011",
}
@article{Johnstone2016,
title = "Hierarchical Bayesian inference for ion channel screening dose-response data",
author = "RH Johnstone and R Bardenet and DJ Gavaghan and GR Mirams",
year = "2016",
journal = "Wellcome Open Research",
pages = "6",
publisher = "Wellcome Trust",
url = "https://wellcomeopenresearch.org/articles/1-6/v1",
volume = "1",
doi = "10.12688/wellcomeopenres.9945.1",
}
@article{Mahoney2016,
title = "Connexin 43 contributes to electrotonic conduction across scar tissue in the intact heart",
author = "VM Mahoney and V Mezzano and GR Mirams and K Maass and Z Li and M Cerrone and C Vasquez and A Bapat and M Delmar and GE Morley",
year = "2016",
journal = "Scientific Reports",
pages = "26744",
publisher = "Nature Publishing Group",
volume = "6",
doi = "10.1038/srep26744",
}
@article{Hill2016,
title = "White Paper: Computational Cardiology and Risk Stratification for Sudden Cardiac Death: One of the Grand Challenges for Cardiology in the 21st Century.",
author = "AP Hill and MD Perry and N Abi-Gerges and J-P Couderc and B Fermini and JC Hancox and BC Knollmann and GR Mirams and J Skinner and W Zareba and JI Vandenberg",
year = "2016",
journal = "Journal of Physiology",
doi = "10.1113/JP272015",
}
@article{Davies2016,
title = "Recent developments in using mechanistic cardiac modelling for drug safety evaluation",
author = "MR Davies and K Wang and GR Mirams and A Caruso and D Noble and A Walz and T Lavé and F Schuler and T Singer and L Polonchuk",
year = "2016",
journal = "Drug Discovery Today",
number = "6",
pages = "924–938",
volume = "21",
doi = "10.1016/j.drudis.2016.02.003",
}
@article{Mirams2016,
title = "White Paper: Uncertainty and variability in computational and mathematical models of cardiac physiology",
author = "GR Mirams and P Pathmanathan and RA Gray and P Challenor and RH Clayton",
year = "2016",
journal = "Journal of Physiology",
doi = "10.1113/JP271671",
}
@article{CooperWebLab2016,
title = "The Cardiac Electrophysiology Web Lab",
author = "Cooper, Jonathan and Scharm, Martin and Mirams, Gary",
year = "2016",
journal = "Biophysical Journal",
number = "2",
pages = "292-300",
volume = "110",
doi = "10.1016/j.bpj.2015.12.012",
}
@article{Johnstone2016,
title = "Uncertainty and variability in models of the cardiac action potential: can we build trustworthy models?",
author = "RH Johnstone and ET Chang and R Bardenet and TP de Boer and DJ Gavaghan and P Pathmanathan and RH Clayton and GR Mirams",
year = "2016",
journal = "Journal of Molecular and Cellular Cardiology",
pages = "49-62",
volume = "96",
doi = "10.1016/j.yjmcc.2015.11.018",
}
@article{cooper2015cce,
title = "Cellular cardiac electrophysiology modelling with Chaste and CellML",
author = "Jonathan Cooper and Raymond Spiteri and Gary Mirams",
year = "2015",
journal = "Frontiers in Physiology",
month = "January",
pages = "511",
url = "http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00511",
volume = "5",
doi = "10.3389/fphys.2014.00511",
}
@article{Samanta2015,
title = "Ca2+ Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca2+-Dependent Nuclear Gene Expression",
author = "Krishna Samanta and Pulak Kar and Gary R. Mirams and Anant B. Parekh",
year = "2015",
journal = "Cell Reports",
number = "2",
pages = "203-216",
url = "http://dx.doi.org/10.1016/j.celrep.2015.06.018",
volume = "12",
doi = "10.1016/j.celrep.2015.06.018",
}
@article{Capel2015,
title = "Hydroxychloroquine reduces heart rate by modulating the hyperpolarisation activated current ‘If’: Novel electrophysiological insights and therapeutic potential",
author = "R.A. Capel and N Herring and M Kalla and A Yavari and G.R. Mirams and G. Douglas and G. Bub and K. Channon and D.J. Paterson and D. Terrar and R-A Burton",
year = "2015",
journal = "Heart Rhythm",
number = "10",
pages = "2186–2194",
url = "http://dx.doi.org/10.1016/j.hrthm.2015.05.027",
volume = "12",
doi = "10.1016/j.hrthm.2015.05.027",
}
@article{williams2015,
title = "A web portal for in-silico action potential predictions",
author = "Geoff Williams and Gary Mirams",
year = "2015",
journal = "Journal of Pharmacological and Toxicological Methods",
pages = "10-16",
url = "http://dx.doi.org/10.1016/j.vascn.2015.05.002",
volume = "75",
doi = "10.1016/j.vascn.2015.05.002",
}
@article{Wang2015,
title = "Cardiac Tissue Slices: Preparation, Handling, and Successful Optical Mapping",
author = "K Wang and P Lee and GR Mirams and P Sarathchandra and T Borg and DJ Gavaghan and P Kohl and C Bollensdorff",
year = "2015",
journal = "American Journal of Physiology: Heart and Circulatory Physiology",
pages = "H1112-H1125",
url = "http://ajpheart.physiology.org/content/308/9/H1112",
volume = "308",
doi = "10.1152/ajpheart.00556.2014",
}
@article{Walmsley2015,
title = "Application of stochastic phenomenological modelling to cell-to-cell and beat-to-beat electrophysiological variability in cardiac tissue",
author = "Walmsley, John and Mirams, Gary R and Pitt-Francis, Joe and Rodriguez, Blanca and Burrage, Kevin",
year = "2015",
journal = "Journal of theoretical biology",
pages = "325--336",
publisher = "Academic Press",
volume = "365",
doi = "10.1016/j.jtbi.2014.10.029",
}
@article{Mirams2014,
title = "Prediction of Thorough QT study results using action potential simulations based on ion channel screens",
author = "GR Mirams and MR Davies and SJ Brough and MH Bridgland-Taylor and Y Cui and DJ Gavaghan and N Abi-Gerges",
year = "2014",
journal = "Journal of Pharmacological & Toxicological Methods",
number = "3",
pages = "246-254",
volume = "70",
doi = "10.1016/j.vascn.2014.07.002",
}
@article{Osborne2014TenSimple,
title = "Ten simple rules for effective computational research",
author = "Osborne, James M and Bernabeu, Miguel O and Bruna, Maria and Calderhead, Ben and Cooper, Jonathan and Dalchau, Neil and Dunn, Sara-Jane and Fletcher, Alexander G and Freeman, Robin and Groen, Derek and others",
year = "2014",
journal = "PLoS Computational Biology",
number = "3",
pages = "e1003506",
publisher = "Public Library of Science San Francisco, USA",
volume = "10",
doi = "10.1371/journal.pcbi.1003506",
}
@article{Elkins2013,
title = "Variability in high-throughput ion channel screening data and consequences for cardiac safety assessment",
author = "Ryan C. Elkins and Mark R. Davies and Stephen J. Brough and David J. Gavaghan and Yi Cui and Najah Abi-Gerges and Gary R. Mirams",
year = "2013",
journal = "Journal of Pharmacological and Toxicological Methods",
keywords = "high-throughput, compound screening, variability, uncertainty, cardiac safety, action potential, mathematical model",
number = "1",
pages = "112-122",
volume = "68",
doi = "10.1016/j.vascn.2013.04.007",
}
@article{Beattie2013,
title = "Evaluation of an In Silico Cardiac Safety Assay: Using Ion Channel Screening Data to Predict QT Interval Changes in the Rabbit Ventricular Wedge",
author = "Kylie A. Beattie and Chris Luscombe and Geoff Williams and Jordi Munoz-Muriedas and David J. Gavaghan and Yi Cui and Gary R. Mirams",
year = "2013",
journal = "Journal of Pharmacological and Toxicological Methods",
number = "1",
pages = "88-96",
url = "http://www.sciencedirect.com/science/article/pii/S105687191300244X",
volume = "68",
doi = "10.1016/j.vascn.2013.04.004",
}
@article{Walmsley2013,
title = "mRNA expression levels in failing human hearts predict cellular electrophysiological remodelling: A population-based simulation study",
author = "Walmsley, J. and Rodriguez, J.F. and Mirams, G.R. and Burrage, K. and Efimov, I.R. and Rodriguez, B.",
year = "2013",
journal = "PLoS ONE",
number = "2",
pages = "e56359",
volume = "8",
doi = "10.1371/journal.pone.0056359",
}
@article{MiramsChaste2013,
title = "Chaste: an open source C++ library for computational physiology and biology",
author = "Mirams, Gary R and Arthurs, Christopher J and Bernabeu, Miguel O and Bordas, Rafel and Cooper, Jonathan and Corrias, Alberto and Davit, Yohan and Dunn, Sara-Jane and Fletcher, Alexander G and Harvey, Daniel G and others",
year = "2013",
journal = "PLoS computational biology",
number = "3",
pages = "e1002970",
publisher = "Public Library of Science San Francisco, USA",
volume = "9",
doi = "10.1371/journal.pcbi.1002970",
}
@article{Zemzemi2012,
title = "Computational assessment of drug-induced effects on the electrocardiogram: from ion channel block to body surface potentials",
author = "N Zemzemi and MO Bernabeu and J Saiz and J Cooper and P Pathmanathan and GR Mirams and J Pitt-Francis and B Rodriguez",
year = "2013",
journal = "British Journal of Pharmacology",
number = "3",
pages = "718-733",
volume = "168",
doi = "10.1111/j.1476-5381.2012.02200.x",
}
@article{sher2011,
title = "A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to Cardiac Ionic Channel Modelling",
author = "Sher, A. and Wang, K. and Wathen, A. and Maybank, P.J. and Mirams, G.R. and Abramson, D. and Noble, D. and Gavaghan, D.J.",
year = "2013",
journal = "Future Generation Computer Systems",
number = "2",
pages = "591-598",
volume = "29",
doi = "10.1016/j.future.2011.09.006",
}
@inproceedings{Mirams2013SPS,
title = "Evaluation of computational modelling as a preclinical proarrhythmic safety assay",
author = "G Mirams and K Beattie and Y Cui and C Luscombe and G Williams and D Gavaghan and N McMahon",
year = "2013",
journal = "Journal of Pharamcological and Toxicological Methods",
number = "1",
pages = "e21",
volume = "86",
doi = "10.1016/j.vascn.2013.01.081",
}
@inproceedings{Walmsley2013b,
title = "Estimation of conductivity tensors from human ventricular optical mapping recordings",
author = "J. Walmsley and G.R. Mirams and I.R. Efimov and K. Burrage and B. Rodriguez",
year = "2013",
booktitle = "Functional Imaging and Modeling of the Heart",
journal = "Lecture Notes in Computer Science",
pages = "224--231",
volume = "7495",
}
@article{Mirams2012CryptInvasion,
title = "A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt",
author = "GR Mirams and AG Fletcher and PK Maini and HM Byrne",
year = "2012",
journal = "Journal of Theoretical Biology",
number = "7",
pages = "143-156",
volume = "312",
doi = "10.1016/j.jtbi.2012.08.002",
}
@article{Mirams2012,
title = "Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing",
author = "Mirams, Gary R. and Davies, Mark R. and Cui, Yi and Kohl, Peter and Noble, Denis",
year = "2012",
journal = "British Journal of Pharmacology",
number = "5",
pages = "932-945",
volume = "167",
doi = "10.1111/j.1476-5381.2012.02020.x",
}
@article{Jonsson2012,
title = "Application of Human Stem Cell-derived Cardiomyocytes in Safety Pharmacology Requires Caution Beyond hERG",
author = "Jonsson, M. and Vos, M.A. and Mirams, G.R. and Duker, G. and Sartipy, P. and de Boer, T.P. and van Veen, T.A.B",
year = "2012",
journal = "Journal of Molecular and Cellular Cardiology",
number = "5",
pages = "998-1008",
url = "http://www.sciencedirect.com/science/article/pii/S0022282812000843",
volume = "52",
doi = "10.1016/j.yjmcc.2012.02.002",
}
@article{Bridge2012,
title = "Distinguishing possible mechanisms for auxin-mediated developmental control in Arabidopsis: Models with two Aux/IAA and ARF proteins, and two target gene-sets",
author = "Bridge, L. J. and Mirams, G. R. and Kieffer, M. L. and King, J. R. and Kepinski, S.",
year = "2012",
issn = "00255564",
journal = "Mathematical Biosciences",
number = "1",
pages = "32-44",
volume = "235",
doi = "10.1016/j.mbs.2011.10.005",
}
@inproceedings{WalmsleyBiophysics2012,
title = "Stochasticity in Action Potential duration Enhances Dispersion of Repolarisation at Fast Pacing Rates",
author = "John Walmsley and Kevin Burrage and Joe M. Pitt-Francis and Gary R. Mirams and Blanca Rodriguez",
year = "2012",
journal = "Biophysical Journal",
number = "3",
pages = "592a-593a",
volume = "102",
doi = "10.1016/j.bpj.2011.11.3230",
}
@article{MiramsNoble2011,
title = "Is it time for in silico simulation of drug cardiac side effects?",
author = "Mirams, G.R. and Noble, D.",
year = "2011",
issn = "0077-8923",
journal = "Annals of the New York Academy of Sciences",
pages = "44-47",
volume = "1245",
doi = "10.1111/j.1749-6632.2011.06324.x",
}
@article{Quinn2011,
title = "Minimum information about a cardiac electrophysiology experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing",
author = "T.A. Quinn and S. Granite and M.A. Allessie and C. Antzelevitch and C. Bollensdorff and G. Bub and R.A.B. Burton and E. Cerbaig and P.S. Chen and M. Delmar and D. DiFrancesco and Y.E. Earm and I.R. Efimov and M. Egger and E. Entcheva and M. Fink and R. Fischmeister and M.R. Franz and A. Garny and W.R. Giles and T. Hannes and S.E. Harding and P.J. Hunter and G. Iribe and J. Jalife and C.R. Johnson and R.S. Kass and I. Kodama and G. Koren and P. Lord and V.S. Markhasin and S. Matsuoka and A.D. McCulloch and G.R. Mirams and G.E. Morley and S. Nattel and D. Noble and S.P. Olesen and A.V. Panfilov and N.A. Trayanova and U. Ravens and S. Richard and D.S. Rosenbaum and Y. Rudy and F. Sachs and F.B. Sachse and D.A. Saint and U. Schotten and O. Solovyova and P. Taggart and L. Tung and A. Varró and P.G. Volders and K. Wang and J.N. Weiss and E. Wettwer and E. White and R. Wilders and R.L. Winslow and P. Kohl",
year = "2011",
journal = "Progress in Biophysics and Molecular Biology",
pages = "4 - 10",
volume = "107",
doi = "10.1016/j.pbiomolbio.2011.07.001",
}
@article{CooperMiramsNiederer2011,
title = "High-throughput functional curation of cellular electrophysiology models",
author = "Cooper J., Mirams G.R., Niederer S.A.",
year = "2011",
editor = "Denis Noble",
journal = "Progress in Biophysics and Molecular Biology",
pages = "11 - 20",
volume = "107",
doi = "10.1016/j.pbiomolbio.2011.06.003",
}
@article{IJNMBE2011a,
title = "The significant effect of the choice of ionic current integration method in cardiac electrophysiological simulations",
author = "P.\ Pathmanathan, G.R.\ Mirams, J.A.\ Southern, and J.P.\ Whiteley",
year = "2011",
journal = "International Journal for Numerical Methods in Biomedical Engineering",
pages = "1751--1770",
volume = "27",
doi = "10.1002/cnm.1438",
}
@article{f20eb73a440003b,
title = "Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk",
author = "Mirams, G. R. and Cui, Y. and Sher, A. and Fink, M. and Cooper, J. and Heath, B. M. and McMahon, N. C. and Gavaghan, D. J. and Noble, D.",
year = "2011",
issn = "00086363",
journal = "Cardiovascular Research",
number = "1",
pages = "53--61",
url = "http://dx.doi.org/10.1093/cvr/cvr044",
volume = "91",
doi = "10.1093/cvr/cvr044",
}
@article{f20ebe88b5163d8,
title = "Novel approaches to assessing cardiac safety-proceedings of a workshop: regulators, industry and academia discuss the future of in silico cardiac modelling to predict the proarrhythmic safety of drugs.",
author = "Fletcher, K. and Shah, R.R. and Thomas, A. and Tobin, F. and Rodriguez, B. and Mirams, G.R. and Saiz, J. and Noble, D.",
year = "2011",
issn = "01145916",
journal = "Drug safety: an international journal of medical toxicology and drug experience",
number = "5",
pages = "439",
volume = "34",
doi = "10.2165/11591950-000000000-00000",
}
@article{f20ea8a70f839df,
title = "A hybrid approach to multi-scale modelling of cancer",
author = "Osborne, J. M. and Walter, A. and Kershaw, S. K. and Mirams, G. R. and Fletcher, A. G. and Pathmanathan, P. and Gavaghan, D. and Jensen, O. E. and Maini, P. K. and Byrne, H. M.",
year = "2010",
journal = "Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences",
month = "Nov",
number = "1930",
pages = "5013--5028",
volume = "368",
doi = "10.1098/rsta.2010.0173",
}
@article{f20eb73a4400032,
title = "A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to L-type Calcium Channel Modelling",
author = "Sher, A. and Wang, K. and Wathen, A. and Mirams, G. and Abramson, D. and Gavaghan, D.",
year = "2010",
journal = "2010 IEEE Sixth International Conference on e ??: Science",
pages = "176--181",
url = "http://www.computer.org/portal/web/csdl/doi/10.1109/eScience.2010.56",
doi = "10.1109/eScience.2010.56",
}
@article{f20ea8a70f839e0,
title = "Modelling Spatially Regulated beta-Catenin Dynamics and Invasion in Intestinal Crypts",
author = "Murray, Philip J. and Kang, JW and Mirams, Gary R. and Shin, SY and Byrne, Helen M. and Maini, Philip K. and Cho, KH",
year = "2010",
journal = "Biophysical Journal",
keywords = "mitochondrial-dna mutations, colon-cancer initiation, stem-cells, colorectal-cancer, wnt, tumorigenesis, instability, expansion, pathway, origin",
number = "3",
pages = "716--725",
volume = "99",
doi = "10.1016/j.bpj.2010.05.016",
}
@inproceedings{5626858,
title = "Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated Guinea Pig ventricular myocytes",
author = "Walmsley, J. and Mirams, G.R. and Bahoshy, M. and Bollensdorff, C. and Rodriguez, B. and Burrage, K.",
year = "2010",
booktitle = "Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE",
issn = "1557-170X",
month = "31 2010-sept. 4",
organization = "IEEE",
pages = "1457--1460",
doi = "10.1109/IEMBS.2010.5626858",
}
@article{f20ea8a70f839dd,
title = "A multiple timescale analysis of a mathematical model of the Wnt/$\beta$-catenin signalling pathway",
author = "Mirams, G. R. and Byrne, H. M. and King, J. R.",
year = "2009",
journal = "Journal of mathematical biology",
month = "Sep",
number = "1",
pages = "131--160",
publisher = "Springer Verlag GMBH Germany",
volume = "60",
doi = "10.1007/s00285-009-0262-y",
}
@article{cancerchaste1,
title = "An integrative computational model for intestinal tissue renewal",
author = "Van Leeuwen and Ingeborg MM and Mirams, GR and Walter, Alex and Fletcher, A and Murray, P and Osborne, J and Varma, S and Young, SJ and Cooper, J and Doyle, B and others",
year = "2009",
journal = "Cell proliferation",
number = "5",
pages = "617--636",
publisher = "Blackwell Publishing Ltd Oxford, UK",
volume = "42",
doi = "10.1111/j.1365-2184.2009.00627.x",
}
@article{f20ea014d691956,
title = "L-TYPE CALCIUM CHANNELS AND CALCIUM REGULATION IN VENTRICULAR MYOCYTES: IN SILICO STUDIES",
author = "Sher, A. and Mirams, G. and Gavaghan, DJ and Noble, D. and Fink, M.",
year = "2009",
issn = "18806546",
journal = "JOURNAL OF PHYSIOLOGICAL SCIENCES ",
pages = "259--259",
volume = "59",
}
@article{chaste_dtm,
title = "A computational study of discrete mechanical tissue models",
author = "P Pathmanathan and J Cooper and A Fletcher and G Mirams and P Murray and J Osborne and J Pitt-Francis and A Walter and S J Chapman",
year = "2009",
journal = "Physical Biology",
number = "3",
volume = "6",
doi = "10.1088/1478-3975/6/3/036001",
}
@article{ChasteCPC09,
title = "Chaste: a test-driven approach to software development for biological modelling",
author = "Pitt-Francis, Joe and Pathmanathan, Pras and Bernabeu, Miguel O and Bordas, Rafel and Cooper, Jonathan and Fletcher, Alexander G and Mirams, Gary R and Murray, Philip and Osborne, James M and Walter, Alex and others",
year = "2009",
journal = "Computer Physics Communications",
number = "12",
pages = "2452--2471",
publisher = "North-Holland",
volume = "180",
doi = "10.1016/j.cpc.2009.07.019",
}
@phdthesis{f20ea8a70f839de,
title = "Subcellular phenomena in colorectal cancer",
author = "Mirams, Gary R.",
year = "2008",
school = "University of Nottingham",
url = "http://etheses.nottingham.ac.uk/archive/00000567",
}