Anna Muszkiewicz presented a poster on "Whole atria mechanisms of inducibility and persistence of atrial fibrillation by depletion of nNOS in human" (A. Muszkiewicz, X. Liu, A. Bueno-Orovio, J. F. Rodriguez, B. Casadei, B. Rodriguez) at the Oxford BHF CRE Annual Symposium 2016.
The NC3Rs and the international Health and Environmental Sciences Institute (HESI;http://www.hesiglobal.org/) are hosting a two day workshop to understand the challenges and opportunities in accelerating acceptance of evidence provided from mathematical models to improve the predictivity of efficacy and safety testing for drugs and chemicals. The workshop will be held in central London on 14 and 15 September 2016.
Alfonso Bueno will be giving a talk at the workshop on the 14th of September at the session "Does model complexity influence confidence", moderated by Syril Petit (HESI), and his talk will be on "Mathematical predictions of cardiac toxicity in human: Advances towards the 3Rs in Safety Pharmacology".
Anna Muszkiewicz presented a poster at the 40TH EWGCCE MEETING on "Computer models of human atrial myocytes and whole atria facilitate investigations into nNOS-mediated mechanisms for atrial fibrillation.", A. Muszkiewicz, X. Liu, A. Bueno-Orovio, J. F. Rodriguez, B. Casadei, B. Rodriguez.
The 40TH EWGCCE MEETING, which is the Official Meeting of the European Working Group on Cardiac Cellular Electrophysiology, was held in Glasgow, United Kingdom, 2-4 Semptember 2016.
Aurore Lyon presented her work on "Distinct ECG-based phenotypes in hypertrophic cardiomyopathy and their association with arrhythmic risk." (Lyon, R. Ariga, A. Minchole, P. Laguna, N. De Freitas, S. Neubauer, H. Watkins, B. Rodriguez) at the European Society of Cardiology.
The ESC Congress was held in Rome, Italy, 27th- 31 of August, 2016. This ESC is the world's largest and most influential cardiovascular congress.
The National Centre for the Replacement, Refinement & Reduction of Animals in Research (known as NC3Rs) has just awarded £500k to Professor Blanca Rodriguez's group on "In Silico human-based methodologies for evaluation of drug safety and efficacy". The award is focused on the research of Blanca's team into cardiotoxicity – a major cause of drug attrition in pharmaceutical development and an area where many thousands of animals are used in safety assessment for drug screening purposes or for in vivo studies.
The aim of this award is to accelerate the use of computer simulation in the research of cardiotoxicity and specific cardiac diseases such as myocardial infarction and heart failure. The team includes an impressive list of collaborators including industry and academic scientists, clinicians and regulators from 11 countries. Using data provided by this international network, a database of human cardiac electrophysiology and contractility in computer models will be created. Research evaluation will compare computer model-based human predictions to clinical outcomes, animal data and in vitro models, with the overall aim of building confidence and capacity in computer modelling.
We are looking for an enthusiastic postdoctoral research associate in Computational Cardiovascular Science at Oxford, as part of the Centre of Research Excellence in Computational Biomedicine funded by the European Commission. The focus of the job is high performance computing simulations of the electromechanical activity of the heart.
The closing date for applications is 12.00 noon on 3 August 2016. Interviews are expected to be held in the week commencing 5 September 2016.
Alfonso Bueno-Orovio visited the School of Mathematical Sciences, Rochester Institute of Technology, USA, on the 21st of July and had the opportunity of giving two talks on "Rediscovering the dynamics of classical physical systems by fractional diffusion." and on "Computer models in biomedicine: What for?".
Alfonso Bueno-Orovio gave a talk on "Rediscovering the dynamics of classical physical systems by fracctional diffusion on the 22th of July at the School of Physics, Georgia Institute of Technology, Atlanta, USA.
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