The 9th TRM Forum on “Computer Simulation of Cardiac Function” is taking place in Lugano, December 4-5, 2017. It is organised by the “Università della Svizzera Italiana” and the Center for Computational Medicine in Cardiology CCMC.
The Forum covers topics on “The atria and cardiac conduction” and “The ventricles and whole heart” where key experts on the field discuss the latest research on Cardiac modelling. More information can be found here.
Blanca Rodriguez is an invited speaker at the session “Translating Atrial Models into Clinical Practice: Mapping, ECG and Pharmacology” with a talk entitled “In silico trials for pharmacology”. She is also co-chairing the session “In Silico Trials and Clinical Trials”.
CompBioMed Webinar No. 1. HPC simulations of cardiac electrophysiology using patient specific models of the heart (using CHASTE and Alya)
The webinar will provide an insight into the latest research in the Computational Cardiovascular Science group on High Performance Computational (HPC) simulations of cardiac electrophysiology using patient specific models of the whole heart. The group has developed an image analysis and computational pipeline for the personalisation of anatomically-based human heart-torso models, from MRI data, generation of volumetric meshes, to patient-specific simulations of human heart function and ECG reconstruction. Regarding the electrophysiological simulations from ionic level up to the whole organ and body surface, we will focus on two well-known simulation softwares, Chaste and Alya. The finite element CHASTE software (Cancer, Heart And Soft Tissue Environment) has been developed at the Department of Computer Science, University of Oxford and the Alya System is the Barcelona Supercomputing Simulation code for high performance computational multi-physics.
The webinar will be given by Ana Minchole and Francesc Levrero-Florencio.
This webinar is part of a series of webinars of the CompBioMed project where we are partners and is made in collaboration with the VPH Institute.
More information on the webinar and the speakers, can be found here. The webinar is free but registration is mandatory.
Patrick MacDonald's islet biology laboratory is a group based in Canada, interested in pancreatic islet function in health and diabetes. Their research projects currently cover several diverse areas of islet cell biology, including: biophysical characterization of islet ion channels; intracellular signal transduction and insulin exocytosis; metabolic/inflammatory interactions; and the cellular regulation of glucagon secretion. They also run an in-house human islet isolation, banking, and distribution program called IsletCore.
Linford will be visiting them from November 8th until November the 22nd and will be learning how to prepare cells for single-cell sequencing, following collecting patch clamp data from them.
The Comprehensive in-vitro Proarrhythmia Assay (CiPA) in-silico Working Group is holding a meeting on 9th November in Toronto alongside the Cardiac Physiome Workshop (7-8th November). The meeting will discuss the US Food and Drug Administration (FDA) modelling group's work on the mathematical modelling aspects of the initiative, gather feedback, hear new ideas and stimulate further collaborations.
CiPA is an international initiative, launched in 2013 by the US Food and Drug Administration, other drug regulatory agencies, industry and academic collaborators, to develop and validate a new mechanistic, in vitro and in silico paradigm for evaluating the proarrhythmic risk of new drugs. CiPA studies include ion channel effects in cell lines combined with mathematical action potential modelling to predict the effect of multiple ion channel block and associated pro-arrhythmic risk, and to check the integrated effect with stem-cell derived cardiomyocyte measurements. The CiPA project website is http://cipaproject.org/
Elisa Passini is an invited speaker at the "Pro-arrhythmic risk markers, validation plans" session.
Elisa Passini and Polina Mamoshina will present our research at the Cardiac Physiome Society's 20th Workshop: Metabolism, Mechanics and Excitation. The Cardiac Physiome Society's annual meeting will be held at the University of Toronto, Canada from Nov. 6th to Nov 9th, 2017.
The main theme of this conference is linking metabolism, signalling, electrophysiology and mechanics, via mathematical models
Polina Mamoshina is giving a talk on “Beyond electrophysiology: Predicting drug-induced cardiotoxicity by combining transcriptome analysis and machine learning" and Elisa Passini is presenting a poster on “Human In Silico Drug Trials in Diseased Populations Predict Clinical Risk of Torsade de Pointes” Elisa Passini, Oliver Britton, Alfonso Bueno-Orovio, Blanca Rodriguez
Kevin Burrage is Professor of Computational Mathematics at the QUT in Brisbane, Australia and he is a formerly Professor of Computational Systems Biology at the Department of Computer Science, from 2007-2015. He was made a Visiting Professor to the Department of Computer Science at the University of Oxford from 2016 to 2019.
His current research interests are on the development of novel modelling and simulation approaches in Computational Biology to capture the underlying variability in dynamical processes and to characterise the heterogeneity in biological tissues through stochastic and nonlocal multiscale techniques.
He will be visiting us from November the 6th until December the 17th, if you are interested, please contact!
Carlos Ledezma, from the Department of Mechanical Engineering, at University College London, is visiting us this week to explore ways of collaboration.
He is part of the Multiscale Cardiovascular Engineering Group (MUSE), supervised by Dr. Vanessa Diaz. Carlos is one of the PhDs of a Marie-Curie Innovative Training Network called VPH-CaSE (http://vph-case.eu), which is funded by the EU Horizon 2020 research and innovation programme under grant agreement No 642612. His research is focused on how to interface in-silico methods, in-vitro experiments and in-vivo explorations.
If you are interested, please contact!
We are now recruiting two motivated PhD candidates for the “Personalised In-Silico Cardiology” (PIC) European Innovative Training Network (ITN). This is a unique opportunity for an exciting 3 year PhD programme coordinated among 10 academic, industrial and clinical institutions, and 9 more associated partners.
Elisa Passini received the Technological Innovation Award at the Safety Pharmacology Society Meeting 2017 for “Virtual Assay: a User-Friendly Framework for In Silico Drug Trials in Populations of Human Cardiomyocyte Models” (Elisa Passini, Oliver Britton, Alfonso Bueno-Orovio, Blanca Rodriguez.)
The Computational Cardiovascular Science team in collaboration with Oxford Computer Consultants and supported by a EPSRC Impact Acceleration Award has developed this user-friendly software for In Silico drug trials, using populations of human cardiac cellular models based on well-understood human cardiac physiology. The human cell populations are calibrated against experimental data and used to predict the effects of different pharmaceutical agents on human cellular response at the population level. Several major companies in the pharmaceutical industry are already using the software with promising results.
Previously, research underpinning Virtual Assay received important awards including Oliver Britton being one of the four finalist at the 2014 UK ICT Pioneers awards and the winner of the 2014 international 3Rs prize by the National Centre for the Replacement Refinement & Reduction of Animals in Research.
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