The Scientific Program of the Safety Pharmacology Society Annual Meeting features a diverse range of scientific sessions organized into two themed tracks and covering issues such as Addressing Safety in Oncology, Translational Safety Pharmacology, Suicidality, New Modalities and New Biological Entities, Disease Models/Personalized Medicine, Microphysiological Systems - New Technologies, In Silico Modeling, Right Species-Right Time, Changing Regulatory Environment among others.
The winner will be announced at the SPS Annual Meeting Meeting in Berlin on Wednesday, September 27 at 08:30.
We have an opening for a full time Grade 7 Research Associate to work within the Computational Cardiovascular Science Team for up to 2 years, with the possibility of extension for up to 3 additional years. The project aims to develop computer models and perform high performance computing studies of the human heart to better understand the deadly inherited heart condition known as Hypertrophic Cardiomyopathy (HCM). The work involves close international, multi-institutional and cross-disciplinary collaborations involving world-experts in clinical and experimental cardiac electrophysiology.
As a researcher on this project, you will contribute to the development of personalised human anatomical models for HCM patients, based on multi-modality magnetic resonance imaging studies; and will conduct high performance computing studies using the personalised models, in order to investigate risk stratification and tailoring of pharmacological therapy in HCM.
The closing date for applications is 12 noon on Friday 22nd September. Interviews will be held on Monday 9th October.
You can find all the information here!
His research aims at understanding the mechanisms that underlie normal and abnormal rhythms of the heart at various levels, from the molecular (ion channel) and cellular to the whole heart. They are also developing a novel noninvasive imaging modality (Electrocardiographic Imaging, ECGI) for the diagnosis and guided therapy of cardiac arrhythmias.
He will be visiting us during September, until mid-October, if you want to meet, please contact!
The Oxford BHF Centre of Research Excellence Annual Research Symposium is held on Thursday 14 September 2017, at The Mathematical Institute Radcliffe Observatory Quarter.
Aurore Lyon is presenting her research on "A computational approach to risk stratification in hypertrophic cardiomyopathy".
Ana Minchole and Hector Martinez are also presenting two posters of our research during the symposium.
The Safety Pharmacology Society Annual Meeting is held in Berlin, 24-27 September 2017.
Elisa Passini will present two posters of our research.The first one is on “In Silico Electro-Mechanical Window Shortening and Repolarisation Abnormalities Predict Clinical Risk of Torsade de Pointes for 40 Reference Compounds, Elisa Passini, Alfonso Bueno-Orovio, Pierre Morissette, Frederick Sannajust, Blanca Rodriguez. And the second one on “Virtual Assay: a User-Friendly Framework for In Silico Drug Trials in Populations of Human Cardiomyocyte Models” Elisa Passini, Oliver Britton, Alfonso Bueno-Orovio, Blanca Rodriguez
A third poster will be presented on “Successful Integrative Approach of the Pro-arrhythmic Risk Assessment of the Multichannel Ion Channel Inhibitor Vanoxerine, via Combination of In-silico Human Cardiomyocyte Models and In-vivo Guinea-pig Electromechanical Window Assay”, Pierre Morissette, Pamela Gerenser, Jeffrey Travis, Patrick Fanelli, Bharathi Balasubramanian Elisa Passini, Alfonso Bueno-Orovio, Blanca Rodriguez, Christopher Regan, Frederick Sannajust.
Computing in Cardiology 2017 is held in Rennes, France, 24-27 September. Aurore Lyon, Peter Marinov and Ana Minchole are giving talks at the conference.
Aurore Lyon is presenting a talk entitled "Investigation of the presence of action potential alternans in hypertrophic cardiomyopathy”.
Peter Marinov is presenting "The Role of the Ina-Ik1 Complex on Human Ventricular conduction Velocity".
And Ana Minchole is giving a talk on “Investigating the Dependency of the QRS Complex with the MRI-based Heart/torso Geometries Using Personalised Computer Models"
The European Society Congress 2017, Saturday 26-Wednesday-30 August 2017 is held in Barcelona, Spain. The ESC meeting is the world's largest cardiovascular congress with over 500 experts sessions and more than 4,500 abstracts contributing to the advancement of cardiovascular medicine worldwide.
Blanca Rodriguez is giving a talk on Saturday the 26th of August on “The future of computer modelling in heart disease” under the session “Computer modelling and simulation”.
The PIC (Personalised in-silico Cardiology) launches on Friday 1st of September 2017. PIC is a 4 year European Innovative Training Network (ITN) that will train a cohort of 15 future innovation leaders able to articulate and materialise this vision where healthcare is guided by in-silico models. These models become virtual reconstructions of an individual, or avatars, to advise doctors about a patients current health status and therapy options. PIC fellows will build and apply models of individual patients to maximise the value of clinical data, helping clinicians deliver a personalised therapy by informing diagnosis, and optimising clinical devices & drug choices.
PIC will address the specific challenges and barriers that face collaborations between clinicians and engineers by encouraging them to work closely together. Fellows will be exposed to the generation of novel academic ideas, the design of practical solutions that meet actual clinical needs, the translation of these ideas into industrial products, and the compliance with safety and regulation requirements. These outcomes will be achieved by pooling the expertise of leading experts from 4 universities, 3 medical equipment companies, and 3 hospital trusts. New talent and innovation will be produced through the training the fellows in computational cardiac modelling, medical imaging & sensing, and clinical devices & instrumentation. These are the key technological areas for developing in-silico driven personalised medicine, and the ability to innovate new healthcare solutions will have a major impact on society’s welfare.
The Computational Cardiovascular Science team is participating on this project and we are currently recruiting! Further information at: http://picnet.eu and on twitter: @PICnetEU
Dr Alfonso Bueno-Orovio has been awarded £542,000 by the British Heart Foundation (BHF) to take up a prestigious Intermediate Fellowship at the University of Oxford.
The deadly inherited heart condition affects about one in 500 of the UK population and is the main cause of sudden cardiac death in children and young adults, but people who have it show few, if any, symptoms. He will collaborate with experts working in computer science, laboratories and clinics to construct computer models of the human heart. These models can then be used to run simulations of how the disease causes dangerous heart
His research has been featured at the Oxfordshire Guardian.
The EHRA EUROPACE-CARDIOSTIM Congress and the 41th Official Meeting of the European Working Group on Cardiac Cellular Electrophysiology will take place in conjunction on 18-19 June 2017 in Vienna – Austria.
Blanca Rodriguez is giving a talk on: “Computational prediction of acquired Long QT and drug-induced Torsades de Pointes.” on the session “the power of electronic health records and computational technologies”.
She is also co-chairing the session “Back to nature? The rise of biologicals to replace catheters, drugs and devices in antiarrhythmic therapy” with Paul volders (Maastricht, Netherlands).
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